Colorectal cancer , also called colon cancer or bowel cancer , includes cancerous growths in the colon , rectum and appendix . It is the third most common form of cancer and in the United States and Europe, colorectal cancer is the second most common visceral neoplasm. Incidence is equally distributed between men and women.
Colorectal malignant tumors are almost always adenocarcinomas. About half of these are sessile lesions of the rectosigmoid area; the rest are polypoid lesions.
Many colorectal cancers are thought to arise from adenomatous polyps in the colon. These mushroom-like growths are usually benign, but some may develop into cancer over time. The majority of the time, the diagnosis of localized colon cancer is through colonoscopy. Therapy is usually through surgery, which in many cases is followed by chemotherapy .
The exact cause of colorectal cancer is unknown, but studies showing concentration in areas of higher economic development suggest a relation to diet (excess animal fat, particularly beef, and low fiber). Other factors that magnify the risk of developing colorectal cancer include:
Signs and symptoms
With proper screening, colon cancer should be detected BEFORE the development of symptoms, when it is most curable.
Most cases of colon cancer have no symptoms. The following symptoms, however, may indicate colon cancer:
Only a tumor biopsy can verify colorectal cancer, but the following tests help detect it:
The most effective treatment for colorectal cancer is surgery to remove the malignant tumor and adjacent tissues as well as any lymph nodes that may contain cancer cells. The type of surgery depends on the location of the tumor:
Chemotherapy is indicated for patients with metastasis, residual disease, or a recurrent inoperable tumor. Drugs used in such treatment commonly include fluorouracil with levamisole, leucovorin, methotrexate, or streptozocin. Patients whose tumor has extended to regional lymph nodes may receive fluorouracil and levamisole for 1 year postoperatively.Radiation therapy induces tumor regression and may be used before or after surgery or combined with chemotherapy, especially fluorouracil.
Unfortunately, colon cancers can be well advanced before they are detected. The most effective prevention of colon cancer is early detection and removal of precancerous colon polyps before they turn cancerous.
If you are over age 50 talk to your doctor about your risks of colorectal cancer, and about what screening tests are appropriate. If screening tests do find polyps, have them removed promptly, to reduce the risk of cancer.
Dietary and lifestyle modifications are important. Some evidence suggests that low-fat and high-fiber diets may reduce your risk of colon cancer. However, even patients who follow strict diets can develop this disease and require colonoscopy.
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