A quantitative analysis of urine uric acid levels may supplement serum uric acid testing when seeking to identify disorders that alter production or excretion of uric acid (such as leukemia, gout, and renal dysfunction).
The most specific laboratory method for detecting uric acid is spectrophotometric absorption after treatment of the specimen with the enzyme uricase.
Procedure and posttest care
Reference valuesNormal urine uric acid values vary with diet but generally are less than 750 mg/24 hours.
Elevated urine uric acid levels may result from chronic myeloid leukemia, polycythemia vera, multiple myeloma, early remission in pernicious anemia, lymphosarcoma and lymphatic leukemia during radiotherapy, or tubular reabsorption defects, such as Fanconi's syndrome and hepatolenticular degeneration (Wilson's disease).Low urine uric acid levels occur in gout (when associated with normal uric acid production but inadequate excretion) and in severe renal damage, such as that resulting from chronic glomerulonephritis, diabetic glomerulosclerosis, and collagen disorders.
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