Alpha1 - AntitrypsinA protein produced by the liver, alpha1 - antitrypsin (also known as AAT or -AT) is believed to inhibit the release of protease into body fluids by dying cells and is a major component of alpha1 globulin. AAT is measured using radioimmunoassay or isoelectric focusing. Congenital absence or deficiency of AAT has been linked to high susceptibility to emphysema.
Procedure and posttest care
Reference valuesAAT levels vary by age, but the normal range is 110 to 200 mg/dl.
Decreased AAT levels may occur in early-onset emphysema and cirrhosis, nephrotic syndrome, malnutrition, congenital alpha1 -globulin deficiency and, transiently, in the neonate.
Increased AAT levels can occur in chronic inflammatory disorders, necrosis, pregnancy, acute pulmonary infections, hyaline membrane disease in infants, hepatitis, systemic lupus erythematosus, and rheumatoid arthritis.
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